Computational Associate
Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area—near Pasadena—and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics, antibodies and cytokines with improved function, with the goal of improving patient outcomes and quality of life. We have an excellent opportunity for a Computational Associate to join our team.
Summary:
Responsible for the development and implementation of tools to advance sequence- and structure-based antibody and protein design, as well as the design and implementation of data pipelines and data visualizations that will impact new drug development candidates.
Job Duties Include:
• Collaborates with cross-disciplinary scientific teams to develop and implement computational tools to advance sequence- and structure-based antibody and protein design
• Works collaboratively with research scientists and technical counterparts to design and implement data pipelines and data visualizations
• Develops data flow pipelines to extract, transform, and load data from various data sources in various data formats
• With guidance and supervision, identifies and develops areas for scientific impact both on internal drug discovery projects and in external publications or open-source efforts
• Synthesizes concepts to push innovative ideas and solutions
• Coordinates and collaborates on research-related tasks across multiple groups
• Communicates data to team members
• Helps prepare SOPs, presentations and technical reports
• May help present data to management in departmental meetings
• Follows all laboratory safety guidelines, practices and protocols
• Adheres to all department and company-wide policies regarding conduct, performance and procedures
• Performs other duties as required.
Job Requirements and Qualifications:
Position minimally requires a Bachelor’s degree in computational biology, bioinformatics, structural biology, computer science, or a related field. Previous relevant experience and industry experience preferred.
Strong proficiency in high level programming languages such as Python or R with experience in version control systems is required. Experience with modern data visualization systems such as R Shiny, Plotly, Spotfire, or Tableau is required.
Preferred knowledge and/or experience includes: protein sequence and structure, particularly those of antibodies. molecular modeling and design tools such as MOE, Schrodinger, or Rosetta, modern molecular biology techniques and laboratory experience, cloud and/or distributed computing, machine learning and statistical modelling for biological data and next-generation sequencing data pipelines and analysis.
The company reserves the right to consider internal experience in lieu of the education or experience requirements listed above.
Position also requires:
• Proficiency in high level programming languages
• Sound knowledge of relational database management including data architecture and
schema design
• Technical expertise with modern data visualization systems
• Ability to work in a fast-paced, matrixed environment
• Ability to adapt to changing priorities
• Strong interpersonal skills
• Ability to work well in a team and independently
• Strong oral and written communication skills
• Ability to work in a fast-paced, goal-oriented multi-project environment
• Ability to understand and follow instructions from supervisors or other team members
• Detail orientation, good documentation practice and strong organizational skills
• Proficiency in MS Office (Word, Excel, Outlook, PowerPoint) and ability to use job relevant software programs
Additional Requirements for Laboratory and Research Related Jobs
This role may involve work with experimental subjects and/or specimens including infected samples, plus various Hazardous Materials and infectious agents (Bloodborne Pathogens, or other potentially infections materials (OPIMs). Therefore, the following are also required:
· Ability to follow the established Environmental Health & Safety rules, procedures, and/or BioSafety Guidelines
· Ability to read and understand Safety Data Sheets (SDSs)
· Ability to be available and willing to work some weekends and evenings to conduct and complete experiments
· Knowledge of biosafety techniques and aseptic/gowning practices
· Experience with laboratory safety standards and procedures, including biohazard handling and disposal techniques, and the ability to ensure laboratory compliance with required safety regulations
· Experience working with biological and chemical hazards, infectious agents, bloodborne pathogens and animal allergens
· Experience working in and maintaining a sterile environment
· Experience working with chemical, and biological hazards
· Thorough knowledge of the operation and maintenance of various lab equipment such as microscopes, centrifuges, spectrophotometers, balances, pH meters, and electrophoresis equipment, freezers, and incubators.
Occasional travel may be required, including travel between Xencor’s Monrovia and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment.
Expected Base Salary Range: $70,000.00 - $80,000.00
The actual salary will be based on the selected candidate’s qualifications, including skills, competencies, education and experience. Xencor offers a competitive total rewards package including 401k match, healthcare coverage, ESPP and a broad range of other benefits. In addition, this position will be eligible for an annual bonus and equity grant. For more information, please see https://xencor.com/careers/.
As a condition of employment, Xencor requires all employees to have received a CDC authorized COVID-19 vaccine regimen and at least one booster dose. New employees will be required to provide proof that at least two weeks have passed since their booster dose as of their start date unless an exemption or accommodation has been requested and approved.
Americans with Disabilities Act (ADA) Statement
The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact HR@xencor.com.
To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.
Equal Employment Opportunity (EEO) Statement
The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.
Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.